As slow-moving Tropical Storm Isaac moves away from New Orleans, surrounding areas of Louisiana are expected to see almost 2 feet of rain and more dangerous floods by the end of the week, while seven tornadoes have spun off from Isaac in Mississippi and Alabama so far.
A tornado that touched down in Gulfport, Miss., has caused the most damage, where significant destruction to homes has been reported. Carlos Redmond, a spokesman for Harrison County Emergency Management, said it's assessing the damage.
"We're looking for daylight. That's what we're looking for. We'll be able to tell a lot more at that time," Redmond told ABC News Thursday.
The U.S. National Hurricane Center said tornadoes are possible along the central Gulf Coast region and parts of the lower Mississippi Valley through Thursday.
The rising waters from rain and flooding have already left locals scrambling up to attics and onto roofs. The main parishes that pose the greatest concern sit around Lake Pontchartrain. With another 4 to 7 inches of rain expected, many officials have expressed worry about the rising waters.
Officials in LaPlace, La., about 25 miles northwest of New Orleans, in St. John the Baptist Parish, called the situation dire.
"I'm afraid the tide is really going to catch some of us off guard tonight," Parish President Layton Ricks told ABC News late Wednesday night.
3100 people have been evacuated in the town since 3 p.m. Wednesday, according to a National Guard officer, with more than 1,000 waiting for rescue in LaPlace as the city sees its worst flooding in 40 years. Housing developments, such as the River Forest subdivision where dozens of families were rescued Wednesday, are under 5 feet of water. The Louisiana National Guard said it would be out in force Thursday across the St. John the Baptist Parish, assisting in rescue efforts.
"It's our own little Katrina," said Tania Trege, wife of St. John the Baptist Parish Sheriff Mike Trege, describing the situation in Laplace.
Towns southwest of New Orleans have already received about 20 inches of rain, with another 4 to 7 inches possible. New Orleans International Airport has officially received 10 inches of rain so far.
As of 5 a.m. ET, Isaac was about 55 miles southeast of Alexandria, La., and about 110 miles northwest of New Orleans. Tropical storms winds extend outward up to 175 miles. Isaac's maximum sustained winds are at 45 mph, according to the U.S. National Hurricane Center in Miami.
A tropical storm warning was still in effect from Cameron, La., to the Mississippi-Alabama state border, according to the Hurricane Center.
An unofficial rainfall total of 22.5 inches was reported in Arabi, La., near the city's 9th Ward on Wednesday. An official report from Audubon Park in New Orleans listed 17 inches of rainfall.
Livingston Parish officials told ABC News that they felt the worst of Isaac at 10 p.m. Wednesday, and expect flooding in the low-lying parts of the parish. Rescue efforts were under way and officials said this will be the first overnight of many water rescues in the area.
Rescue operations are still under way in Plaquemines Parish, where more than 100 people in the parish have been rescued so far. A levee in Plaquemines Parish will be intentionally breached at some point Thursday to relieve pressure on it. That area has been under mandatory evacuation.
One person has been reported dead, according to The Associated Press, compared with 1,800 deaths from Katrina in Louisiana and Mississippi. And police reported few problems with looting.
More than 725,000 homes and businesses throughout Louisiana were without power as of 2 a.m.
In Mississippi, Highway 90 remains shut down, with much of area now submerged in water. 30,000 customers are without power in Gulfport, Miss., alone, where an apparent tornado spawned by the storm ripped a house from ground.
In Biloxi, powerful winds are ravaging the city as residents begin to worry about raw sewage and mold.
President Obama declared federal emergencies in Louisiana and Mississippi late Wednesday, according to a statement from the White House. The disaster declarations free up federal aid for affected areas.
Of Louisiana's 64 parishes, 58 are under states of emergency this morning.
Forecasters expected Isaac to move inland over the next several days, dumping rain on drought-stricken states across the nation's midsection before finally breaking up over the weekend. The storm was expected to weaken to a tropical depression Thursday, according to the Hurricane Center.
Five to 10-foot storm surges were expected in Mississippi and southeastern Louisiana, with seven to 14 inches of rain, and some areas could see 25 inches, the center said.
ABC News' Max Golembo and The Associated Press contributed to this report.
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